31211Ideal homes : real homes, real homeowners
Contents: Inspiring homes. Regulars. On the cover. Project showcase. Blend by ImC. Darwin interior. Happe design atelier. Noble interior design. Ovon design.
31212Ideal home's outdoor living handbook : 2nd ed.
Discover the ultimate guide to Outdoor Living! Packed with 39 pages of real gardens, furniture, decor, recipes, and style hacks. Get great-value advice to make the most of your garden this season.
31213Ideas and how-to : additions
Presenting a wealth of inspiring ideas for adding living space, from a modest bumpout to a new room to a full second story and Ideas and before-and-after floor plans for every type of addition, including kitchen and dining areas, family rooms, master suites, sunrooms, and bonus spaces. Expanded-view illustrations of popular projects, Comprehensive overview of options for materials and Smart advice on planning, calculating costs, and working with contractors.
31214Ideas that matter : the worlds of Jane Jacobs
The book is a unique combination of Jacobs' own writing, biography, and analysis by other scholars. Arranged by topic, it sheds light both on the development of Jacobs' theories and on her life. A chapter on "Death and Life of American Cities" reveals a debate between the author and her publisher about changing the book's title.
31215Identification of CYP2C9, VKORC1 genotypes and recommendation of warfarin dose for Vietnamese cardiov ascular patients = Xác định kiểu gen CYP2C9, VKORC1 và khuyến nghị liều dùng warfarin cho bệnh nhân tim mạch Việt Nam
Xác định các kiểu gen của CYP2C9 và VKORC1 trên 96 bệnh nhân bị đau tim hoặc nhồi máu cơ tim tại Việt Nam, từ đó xây dựng phác đồ dùng thuốc warfarin cho các bệnh nhân.
31216Identification of hub genes and drug-gene interactions for targeted breast cancer treatment by integrated bioinformatics analysis
In this study, bioinformatics is applied to genetic testing for BC diagnosis; namely the R programming language combined with the bioinformatics toolkit was used to analyze gene expression levels between normal and tumor tissues in three gene expression profiles (GSE29431, GSE42568, GSE21422).
31217Identification of Panax spp. in the Northern Vietnam based on ITS-rDNA sequence analysis
In order to accurately identify ginseng species (Panax spp.) that grow naturally in some Northern provinces of Vietnam, we collected 30 natural ginseng samples and used nuclear genetic region (ITS-rDNA) for current analysis. The success rate for nuclear genomic region PCR (ITS-rDNA) amplification is 100%. The bidirectional sequence read success rate obtained from the PCR product was 100%, with a nucleotide sequence length of 588 bp. Based on the analysis of ITS-rDNA region results, the samples of ginseng species from Tuyen Quang and Cao Bang provinces have a close relationship with Panax notoginseng (MLBS = 100%), while the samples of ginseng species from Ha Giang and Yen Bai provinces have a close relationship with P. stipuleanatus (MLBS = 99%).
31218Identification of the causative mutation in the ITGB2 gene in a LAD1 patient by whole exome sequencing
Leukocyte adhesion deficiency type 1 (LAD1) is a rare congenital immunodeficiency disease. The cause of disease is determined to be the mutations in the ITGB2 gene that codes for CD18, the beta chain of beta-2 integrins, leads to decreased expression or functioning of CD18. This deficiency leads to severe impairment of leukocyte adhesion to the vascular wall and leukocyte migration to sites of infection and inflammation. LAD1 has also been associated with inhibition of interleukin-23 and interleukin-17 resulting in a hyperinflammatory and chronic inflammation. Patients with LAD1 typically present in early infancy with recurrent, life threatening infections that are frequently fatal before 2 years of age without hematopoietic stem cell transplant (HSCT). However, LAD1 is difficult to diagnose and many LAD1 patients die at a young age despite intensive antibiotic therapy. Accurate diagnosis requires detailed clinical information (delayed umbilical cord loss, severe periodontitis, delayed wound healing and sores, skin abscesses, and recurrent infection), and confirmation the absence of integrins by flow cytometric analysis. A better understanding of the molecular characteristics of this disease is needed to raise awareness and definitive diagnosis infants with LAD1. To definitive diagnosis, whole exome sequencing and Sanger sequencing were performed in an eighteen-month-old boy with severe leukocytosis, recurrent infections, delayed wound healing, and hepatosplenomegaly associated with an acquired cytomegalovirus infection. Two variants: One previously reported mutation (c.533C>T, p.Pro178Leu) and one novel variant (c.59-1G>A), in the ITGB2 gene were detected. These results can be used for definitive genetic diagnosis, genetic counseling, as well as a prenatal diagnosis in LAD1 patients.
31219Identification of the potential compounds for inhibition CD44 target of human breast cancer stem cells by docking method
In a recent cell-based assay, it has been demonstrated that the F-19848A compound inhibits the binding of hyaluronan to the CD44 receptor, which is a cell-surface glycoprotein and a receptor for hyaluronan, a major component of the tumor extracellular matrix. The interaction between CD44 and hyaluronan has been shown to promote breast cancer metastasis according to evidence. In this study, the PubChem database contains more than 112 million compounds. This data is inputted for virtual screening find out top hits by combining Lipinski’s rule and docking method. With 20 configurations obtained by docking method, the lowest binding affinity ΔEbind achieved in the best docking mode was chosen as a scoring function for picking out top ligands. For inhibition the CD44 target, the top-leads compounds with binding energy less than -9.0 kcal.mol-1 and F-19848A have selected. By docking method, the binding site and other quantities were determined such as the number of hydrogen bonds (HB), non-bond contacts (NBC) of top ligands with CD44 target. Besides, the results also showed that the non-bonded contacts dominate over hydrogen bonds in the interaction between top ligands with CD44 target.
31220Identification of variant of insulin receptor gene in resistant diabetes
Insulin resistance is defined as a reduced biological response of target tissues to normal insulin levels and is a major mechanism leading to type 2 diabetes, particularly in obese individuals. Beyond obesity, other causes include medications (e.g., glucocorticoids, antiretrovirals, oral contraceptives), stress, pregnancy, dyslipidemia, insulin receptor autoantibodies (Type B insulin resistance), and genetic defects. Among genetic causes, mutations in the insulin receptor (INSR) gene can lead to severe insulin resistance known as Type A insulin resistance. This rare inherited disorder belongs to a spectrum of monogenic insulin resistance syndromes, including Donohue and Rabson-Mendenhall syndromes.