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Background: Laparoscopic cholecystectomy for acute cholecystitis used to be a contraindication before. However, this method is becoming to be applied more and more because of experiences of surgeons and technical advance. This study was to evaluate the ability, safety and efficacy of this method. Method: Cross-sectional descriptive, retrospective study. Results: 25 patients with acute cholecystitis was applied laparoscopic cholecystectomy. The average of age was 51.21 +/- 7.6. Male/female: 1.5. More than 60 percent of them are in second day of disease. 100 percent had abdominal pain in right upper quadrant. 68 percent had fever of more than 38oC. Ultrasound with thick gall-bladder wall was in 100 percent. Number of white blood was more than 15GIL in 40 percent of patients. Average operating time: 65.2 +/- 12.9 minutes. The average time of hospital stay after operation was 6.8 +/- 2.5 days. Best and middle result was in 92 percent. One case had biliary leakage. Conclusion: Laparoscopic cholecystectomy was a realiable, safe and effective method for treatment of acute cholecystitis.