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Preliminary evaluation of the effectiveness of autologous bone marrow stem cell therapy in supporting the treatment of biliary atresia

Tác giả: Nguyen Pham Anh Hoa, Hoang Tuan Khang , Pham Duy Hien, Nguyen Thanh Binh, Dang Thi Ha, Bach Thi Ly Na , Pham Thi Hai Yen, Tran Duc Tam, Phan Hong Long, Vu Manh Hoan, Nguyen Duc Hanh, Nguyen Duc Thanh, Tran Thi Thu Huyen
Số trang: P. 120-129
Số phát hành: Tập 190 - Số 6
Kiểu tài liệu: Tạp chí trong nước
Nơi lưu trữ: 03 Quang Trung
Mã phân loại: 610
Ngôn ngữ: Tiếng Anh
Toàn văn: https://thuvienso.duytan.edu.vn/handle/123456789/347239
Từ khóa: Biliary atresia, Kasai operation, autologous bone marrow stem cells, treatment outcomes, safety
Chủ đề: Pediatrics
Tóm tắt:

Biliary atresia (BA) is a rare hepatobiliary disorder. Stem cell therapy is expected to serve as a supportive treatment to slow fibrosis progression. This study aimed to assess the therapeutic efficacy and the safety of the Kasai procedure combined with autologous bone marrow stem cell (ABMSC) infusion. From May 2021 to December 2024, 82 pediatric BA patientswho underwent the combined treatment at Vietnam National Children’s Hospital were enrolled. The mean age at surgery was 76.8 ± 12.6 days. No severe complication occurred during stem cell harvesting or follow-up time frame. T

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