Boga-TN is a formula originating from herbal medicines that are used to treat liver disorders; however, its toxicity is not yet investigated. Therefore, this study was conducted to assess the acute and sub-chronic toxicity of Boga-TN tablets in experimental animals. Acute toxicity study was performed via Swiss mice, with a single oral dose, and followed up to seven days according to World Health Organization Guidance. No sign of acute oral toxicity was detected, and the LD50 Boga-TN was estimated to be more than 60.38 g/kg.
This research evaluated the acute and subchronic toxicities of BTL lozenges through oral administration in experimental animals. The acute toxicity was determined by Litchfield Wilcoxon method in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO and OECD in Wistar rats with oral doses of 720 g/kg body weight/day (equal to recommended human dose) and 1440 g/kg body weight/day (2 times as high as recommended human dose) in 90 consecutive days.
The research evaluated the acute and subchronic toxicities of An Nguyet Khang tablets in experimental animals. Acute toxicity was defined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by WHO and OECD's recommendation in Wistar rats with oral doses of 0.65 g/kg/day (equal to recommended human dose) and 1.95 g/kg/day (3 times as high as recommended human dose) in fourconsecutive weeks.
The genotoxic potential of KOVIR capsules was investigated in vivo using the mammalian bone marrow chromosomal aberration test. Four groups of mice, seven in each group, were used in the study: Group I served as vehicle control; Group II received the positive control (cyclophosphamide 50 mg/kg; single dose; intraperitoneal route); and Group III to IV were given orally the KOVIR capsules, suspended in distilled water, at a single test dose of 2.16 and 4.32 capsules/kg, respectively. The obtained data disclosed the safety of KOVIR capsules, which did not show substantial genotoxic effects at either dose when compared with the vehicle group.
The present study was performed to gather information on the effects of Kovir capsules on reproductive and developmental parameters in mice according to the OECD guideline for reproductive/developmental toxicity screening test. The test item was administered orally at dose levels of 1.44 and 2.16 capsules/kg body weight/day to male mice from 2 weeks before mating to the end of the 14-day mating period and females from 2 weeks before mating, during mating, gestation, and until the 13th day of lactation. During the study period, clinical signs, body weight, relative organ weight, reproductive and littering results, necropsy results, and histopathological examination of the testicles were examined.
This study investigates the antioxidant activity and potential hepatoprotective of Hypericum sampsonii extract (BLD1 extract) in vitro and in vivo. The in vitro experiment was carried out with DPPH (1, 1-diphenyl-2-picrylhydrazyl) radical scavenging assay to assess the antioxidant properties of BLD1 extract. In the in vivo experiment, the hepatoprotective activity of BLD1 extract was evaluated on an acetaminophen-induced hepatotoxicity mouse model. The in vitro assay demonstrated that the extract exhibited antioxidant activity in a dose-dependent manner. In the in vivo experiments, BLD1 extract at both doses (3.6 g/kg b.w day and 10.8 g/kg b.w day) reflected the decrease in serum ALT, AST and MDA level. Hepatic histology was also investigated post-mortem to assess the degree of liver injury. The overall findings of this study demonstrate the potential hepatoprotective effect of Hypericum sampsonii in acetaminophen-induced oxidative stress and liver toxicity in mice. This study has established the efficacy of Hypericum sampsonii, which should warrant further clinical trials and applications.
Available anti-ulcer drugs unveil partial effectiveness and numerous adverse reactions. Plants offer an alternative strategy in the search for new drugs in the therapy and prevention of peptic ulceration. The present study investigated the possible protective effect of the herbal formulation Vien Khoi Tim (VKT) on indomethacin-induced gastric mucosal damage in rats. VKT was tested at two doses (1.44 & 0.48 capsules/kg/d po) ten days before the indomethacin single-dose challenge (40 mg/kg po). Animals were sacrificed six hours after indomethacin administration, and gastric tissues were collected for gross observation and histopathological analyses. The results revealed that the administration of indomethacin caused evident gastric mucosal damage with morphological and histological manifestations. VKT pretreatment tended to avert the rise in lesion numbers, reduce the ulcer index, and improve the severity of bleeding streaks and epithelial sloughing in gastric mucosa on the macroscopic examination compared to the model group. It is worth noting that no ulcerative lesions were observed in the gastric tissues of rats receiving VKT upon microscopic examination.
Evaluate the acute and subchronic toxicities of “Com kien ty” through oral administration in experimental animals. The acute toxicity was determined using the Litchfield Wilcoxon method in mice. Following WHO's recommendation, the subchronic toxicity was assessed in rabbits with oral doses of 0.9 g/kg/day (equal to the recommended human dose) and 2.7 g/kg/day (3 times as high as the recommended human dose) in 4 consecutive weeks. Results showed “Com kien ty” at the highest dose of 60.0 g/kg did not express acute toxicity in mice. Regarding the subchronic toxicity test, after oral administration of “Com kien ty”, hematological parameters, hepato-renal functions were unchanged as compared with the control group, and no gross lesions in organs were observed in all experimental animals. In conclusion, “Com kien ty” did not produce acute and subchronic toxicities in Swiss mice and New Zealand rabbits.
The study was conducted to assess the immunostimulatory effect of Hericium Erinaceus on cyclophosphamide-induced immunodeficient mice. Animals were administered Hericium Erinaceus orally at 0.72 g/kg b.w and 1.44 g/kg b.w for seven consecutive days. On the 4th day, CP (200 mg/kg) was intraperitoneally injected into mice.
This is a cross-sectional study conducted on 137 post-stroke patients aged ≥ 60 years old treated at the National Geriatric Hospital to explore some factors related to domains of comprehensive geriatric assessment (CGA). The components of CGA assessed were medical status (nutrition; urinary incontinence, frailty, visual and hearing ability), functional status (Barthel index, instrumental activity daily living, risk of fall) and neuropsychological status (cognition and depression).
