CSDL Bài trích Báo - Tạp chí
chủ đề: Dengue virus
1 Prediction of conservative epitopes in the NS1 sequences of all four dengue virus serotypes / Hoang Xuan Cuong, Vu Minh Thuong, Do Nhu Binh, Dao Duc Tien, Bui Thuy Linh, Vo Thi Bich Thuy // .- 2023 .- Vol 21 - Number 3 .- P. 443-454 .- 610
The Dengue virus, transmitted by Aedes aegypti mosquitoes, causes dengue fever, a life-threatening illness. NS1 (Nonstructural Protein 1) has been widely used as a biomarker for detecting dengue due to its early occurrence, high sensitivity, and specificity. The main objective of this study was to design an epitope-rich peptide capable of identifying all four dengue serotypes using homology modeling. Homology protein modeling, a computational approach, predicts the 3D structure of a protein by comparing its sequence to a known template. To achieve this goal, various bioinformatics tools, such as Blast/NCBI, BepiPred, Discotope 2.0, and HADDOCK, were utilized.
2 Expression of global consensus non-structural protein 1 (NS1) of dengue virus serotypes 1 and 2 in Nicotiana benthamiana / Cu Le Nguyen, Nguyen Ngoc Luong, Tuong Quoc Trieu, Nguyen Hoang Loc // .- 2023 .- Vol 21 - Number 3 .- P. 513-529 .- 610
Dengue viruses, which consist of four distinct serotypes, belong to the Flavivirus family, one of the most important arthropod-borne pathogen groups for humans. Vietnam is among the tropical countries that have endemic dengue outbreaks, and in 2022, the number of infections as well as fatal cases reached a record high, causing a great economic burden to the public health system. Although all four dengue serotypes have been circulating in Vietnam, serotypes 1 and 2 have been dominating in the last few decades.