CSDL Bài trích Báo - Tạp chí
Prediction of conservative epitopes in the NS1 sequences of all four dengue virus serotypes
Tác giả: Hoang Xuan Cuong, Vu Minh Thuong, Do Nhu Binh, Dao Duc Tien, Bui Thuy Linh, Vo Thi Bich Thuy
Số trang:
P. 443-454
Số phát hành:
Vol 21 - Number 3
Kiểu tài liệu:
Tạp chí trong nước
Nơi lưu trữ:
03 Quang Trung
Mã phân loại:
610
Ngôn ngữ:
Tiếng Anh
Từ khóa:
Dengue virus, NS1, serotypes, epitope, homology modeling
Chủ đề:
Dengue virus
Tóm tắt:
The Dengue virus, transmitted by Aedes aegypti mosquitoes, causes dengue fever, a life-threatening illness. NS1 (Nonstructural Protein 1) has been widely used as a biomarker for detecting dengue due to its early occurrence, high sensitivity, and specificity. The main objective of this study was to design an epitope-rich peptide capable of identifying all four dengue serotypes using homology modeling. Homology protein modeling, a computational approach, predicts the 3D structure of a protein by comparing its sequence to a known template. To achieve this goal, various bioinformatics tools, such as Blast/NCBI, BepiPred, Discotope 2.0, and HADDOCK, were utilized.