1 Effects of rubiadin-3-methyl ether on the immune properties of hUC-MSCs / Nguyen Thi Sam, Nguyen Thi Huyen, Nguyen Thi Phuong-Anh, Pham The Dan, Nguyen Thi Thuy-Ngan, Nguyen Manh Cuong, Chu Hoang Ha, Nguyen Trung Nam // .- 2023 .- Vol 21 - Number 1 .- P. 15-19 .- 610

Mesenchymal stem cells (MSCs) have become an effective tool for treating immune-related diseases due to their multilineage potential and immunomodulatory capabilities. One of the main factors contributing to their immunomodulatory capabilities is the IDO cascade, which was chosen as the main subject in this research. The IDO-Kyn-AHR-CYP cascade was chosen to evaluate the immunomodulatory properties of treated MSCs, with expression levels of the key gene IDO (indoleamine 2,3-dioxygenase) selected as the screening criterion. Cultured human umbilical cord MSCs (hUC-MSCs) were treated with different natural bioactive compounds.