CSDL Bài trích Báo - Tạp chí
Efficient, column-chromatography-free synthesis of Dipterocarpol succinate oxime ester salts
Tác giả: Nguyen Dang Minh Khanh, Nguyen Hoang Long, Nguyen Trong Thien, Le Quang Phong
Số trang:
P. 99-105
Số phát hành:
Số 05(42)
Kiểu tài liệu:
Tạp chí trong nước
Nơi lưu trữ:
03 Quang Trung
Mã phân loại:
540
Ngôn ngữ:
Tiếng Anh
Từ khóa:
Dipterocarpol, natural product semi-synthesis, succinate salt, antimicrobial
Chủ đề:
Chemistry, Analytic--Methodology
Tóm tắt:
Natural-product-based drugs commonly were converted to organic or inorganic salts due to better stability, solubility or membrane-permeability of new salts compared to the drug itself. In this report, succinate oxime ester of dipterocarpol was synthesized successfully in a simple column chromatography-free isolation process. The oxime ester acid was then reacted with various organic, inorganic base to create different counterion salts. Two derivatives were shown to be stable for a period of time for future antimicrobial evaluation.