Tóm tắt:

Natural-product-based drugs commonly were converted to organic or inorganic salts due to better stability, solubility or membrane-permeability of new salts compared to the drug itself. In this report, succinate oxime ester of dipterocarpol was synthesized successfully in a simple column chromatography-free isolation process. The oxime ester acid was then reacted with various organic, inorganic base to create different counterion salts. Two derivatives were shown to be stable for a period of time for future antimicrobial evaluation.