Tóm tắt:

Neoadjuvant chemotherapy (NACT) with the FLOT regimen (5-Fluorouracil, Leucovorin, Oxaliplatin, Docetaxel) has shown promising results for locally advanced gastric cancer (LAGC). This study aimed to evaluate the initial treatment outcomes of LAGC patients receiving neoadjuvant FLOT at Hanoi Oncology Hospital. A descriptive cohort study was conducted on 35 patients with LAGC (cT3-4 and/or cN2-3, M0) treated with neoadjuvant FLOT between October 2021 and February 2024. Clinical data, radiological and histopathological responses, surgical outcomes, and adverse events were retrospectively and prospectively collected and analyzed.