22281Genetic variations of filaggrin encoding gene (FLG) in the Vietnamese population revealed from whole-exome sequencing
Filaggrin is a key protein that facilitates terminal differentiation of the epidermis and maintains skin barrier function. Mutations in the gene encoding filaggrin (FLG) have been identified to cause ichthyosis vulgaris, increase the risk of atopic dermatitis and other skin diseases. In this study, we established the database of FLG gene obtained by whole-exome sequencing (WES) of 244 Vietnamese. We also estimated allele and genotype frequencies of the FLG gene in this Vietnamese population and predicted the impact of novel variants on protein function using in silico analysis tools. The detected variants included 126 nonsynonymous, six nonsense mutations, six frameshift insertions/deletions, and one non-frameshift deletion, mostly located in exon 3. Of which, there were 11 novel variants have been identified and four of them were predicted as detrimental for encoding protein. Remarkable pathogenic variants were mostly nonsense variants, showing the main genetic factor underlying the pathology of diseases caused by FLG.
22282Genetics : a conceptual approach : 3rd edition
Based on the author’s 27 years of teaching experience, Genetics: A Conceptual Approach, Third Edition, builds upon features that have made past editions so successful: an engaging writing style; relevant applications; an accessible and instructive art program; an emphasis on problem-solving; and, most importantly, a strong focus on concepts and connections. To bring these key concepts into sharper focus, Ben Pierce has selectively reduced the amount of detail and has streamlined coverage to focus on essential concepts.
22283Genetics : analysis & principles : 3rd ed.
Genetics: Analysis and Principles is a one-semester, introductory genetics textbook that takes an experimental approach to understanding genetics. By weaving one or two experiments into the narrative of each chapter, students can simultaneously explore the scientific method and understand the genetic principles that have been learned from these experiments.
22284Genetics : analysis of genes and genomes : 5th ed.
This introductory college level textbook covers the basic processes of gene transmission, mutation, expression, and regulation. Hartl and Jones present an integrated view of the modern world of genetics, treating classical, molecular, and population genetics as unif.
22285Genetics : analysis of genes and genomes : 6th ed.
Providing the most current, clear, comprehensive and balanced introduction to genetics and genomics at the college level. It streat transmission genetics, molecular genetics, and evolutionary genetics as fully integrated subjects, and provides students with an unprecedented understanding of the basic processes of gene transmission, mutation, expression and regulation.
22286Genetics : from genes to genomes
This new edition builds upon the integration of Mendelian and molecular principles, providing students with the links between early genetics understanding and the new molecular discoveries that have changed the way the field of genetics is viewed.
22287Genetics : from genes to genomes with powerweb : 2nd ed.
This book continues to build upon the integration of Mendelian and molecular principles, providing students with the links between early genetics understanding and the new molecular discoveries that have changed the way the field of genetics is viewed.
22288Genetics for dummies : 2nd ed.
A practical guide that gets you up to speed on all the fundamentals and the most recent discoveries in genetics, in easy-to-understand terms. You'll see how people are applying genetic science to fight disease, develop new products, solve crimes-- and even clone cats!.
22289Genome analysis : a laboratory manual
Meiotic mapping in humans; Genetic and comparative mapping in mice; Identification and analysis of DNA polymorphisms;…
22290Genome analysis : a laboratory manual
Purifying and analyzing genomic DNA; Preparation, manipulation, and mapping of HMW DNA; PCR in genome analysis;...