Primary mucinous carcinoma of the skin (PMCS) is an extremely uncommon skin cancer originating from sweat glands. We present a case of a male patient diagnosed with PMCS who was initially misdiagnosed with benign sebaceous cysts. A 62-year-old male patient presented to a private clinic with a chief complaint of a slowly progressing nodule located under his lower lip for the past two years; The nodule was locally excised . The histopathology analysis yielded a diagnosis of mucinous carcinoma with a positive circumferential margin. Reexcison was performed, and the final histopathology result was a small nest of mucinous carcinoma with a negative surgical margin.
Ich phu dan capsules are intended to treat menstrual pain. The study aimed to assess the analgesic effects of Ich phu dan capsules in animal models. Three animal models were used: a hot plate, tail flick and acetic acid-induced writhing test.
The study aimed to determine the smoking prevalence and explore the association between smoking and viral load among people living with HIV who are drug users (HIV+ PWID) in Vietnam. We used secondary data from a descriptive cross-sectional study of 280 HIV+ PWID in an open-label, non-inferiority trial from July 2015 to February 2018 at six HIV clinics in Northern Vietnam.
To describe the clinical characteristics of dissociative disorders, a cross- sectional study was conducted on 57 adolescent patients diagnosed with dissociative disorder, from December 2021 to June 2023, at the Adolescent Health Department - Vietnam National Children's Hospital.
Trans-Cinnamaldehyde, an α, β-unsaturated aromatic aldehyde, was a derivative of Cinnamonnum obtusifolium - Lauraceae; its bioavailability allows it to be used in the treatment of fungal infections as Candida species causing opportunistic fungal infections are common today. Antibiotic resistance in fungi is often due to their ability to form biofilm. Therefore, new substances with antibiofilm were being investigated as alternative treatment. Representatives of Candida spp. were used to determine the MIC, MBIC50, MBIC80, MBIC100, and MFC of trans-Cinnamaldehyde compared to Nystatin which is used for treatment of Candida infections in Vietnam. The most important antibiofilm effect of trans-Cinnamaldehyde was demonstrated by the CLSI M27-A2 method. Trans-Cinnamaldehyde was given MBIC100 higher than PMIC from 10 to 20 times, while Nystatin was given MBIC100 higher than PMIC from 5 to 20 times. In addition, PMFC of trans-Cinnamaldehyde was equivalent (Candida albicans and Candida tropicalis) or only twice (Candida glabrata) PMIC. The jump in Candida biofilm inhibitory activity was short, from MBIC50 to MBIC100 (no intermediate value, MBIC80). Trans-Cinnamaldehyde extract, compared to Nystatin, had a generally similar effect in preventing the growth and loss of Candida spp. both in biofilm and planktonic form and was somewhat more effective against Candida spp. in biofilm form.
Knee osteoarthritis is one of the most common joint disorders of older individuals. It is a painful and disabling disease characterized by pain, stiffness. However, in Vietnam, the number of studies on this issue is still very limited, especially those on physical function. This study aimed to evaluate physical function in 178 elderly patients with knee OA. A cross-sectional study was utilized. Physical function was assessed by The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Timed up and go test (TUG).
This pilot study first aimed to evaluate the safety and efficacy of this twenty-day auricular acupressure using Semen Vaccariae (Wang Bu Liu Xing) in improving the sleeping conditions of primary insomnia patients. The secondary aim was to evaluate the improvement of some other self-reported symptoms caused by insomnia. A clinical prospective pre–post study was designed, enrolling 60 primary insomnia patients. Each patient was administered the auricular acupressure on five acupoints of NADA protocol of both ears by applying the Vaccariae seeds and was instructed to gently press 1 minute/acupoint each time, four times a day for twenty consecutive days.
Health-related quality of life (HRQoL) is increasingly recognized as one of the goals of holistic healthcare. Crohn's disease is the most common inflammatory bowel disease that necessitates long-term management and increases the risk of psychological distress and social disruption, leading to impaired HRQoL in comparison to healthy controls. We administered the PedsQLTM 4.0 scale to 40 children aged 2 to 17 years with Crohn’s disease and their parents to evaluate the HRQoL of patients and define the variables that impact these individuals. Our study indicated that children with Crohn's disease experienced a decrease in their HRQoL in school functioning. We found that factors related to decreased quality of life in these patients included gender (female), stunting, living in low-income families, higher disease activity index, and undergoing surgical intervention.
Report describes the first cases in Vietnam that identified pathogenic/likely pathogenic variants by NIPT-SGD in fetuses. These findings were compared with the diagnostic testing (whole exome sequencing/WES) on amniotic fluid/placenta tissue/umbilical cord blood samples. Single-gene NIPT detected pathogenic variants in the fetuses on TSC2, FGFR3, FGFR2 (two cases), and PTPN11 genes. All results coincided with the subsequent diagnosis. Preliminary research showed the potential of cell-free fetal DNA analysis for prenatal screening of dominant single-gene mutations.
Evaluated the correlation between plasma renin concentration (PRC) and plasma renin activity (PRA), and then PAC/PRC and PAC/PRA ratios on Maglumi 800 immunoassay analyzer. Forty-five plasma samples from volunteers were collected. PRC, PRA and PAC were measured by Maglumi 800 - a fully-auto chemiluminescence immunoassay analyzer. Correlation between plasma renin concentration (PRC) and plasma renin activity (PRA), and then PAC/PRC and PAC/PRA ratios were determined by regression analysis. PRC and PRA showed a good correlation (r = 0.88). The PAC/PRC and PAC/PRA ratios have a similar relationship (r = 0.757). Because of the advantages of the procedure and the independence of PRC from endogenous angiotensinogen levels, PRC may be used preferentially over PRA as high throughput screening tool.
