CSDL Bài trích Báo - Tạp chí
chủ đề: Pharmacology
1 Protective and curative effects of Phuong Dong Dai Trang tablets on an experimental model of irritable bowel syndrome / Tran Thanh Tung, Pham Thi Van Anh, Dau Thuy Duong // .- 2024 .- Volume 184 E15 - N 11 .- P. 87-95 .- 615
Phuong Dong Dai Trang tablet is a mixture of medicinal herbs including Hedychium coronarium, Coix lacryma-jobi, Dioscorea persimilis, Cynara Scolymus L., Paeonia lactiflora, and Glochidion eriocarpum. This study was carried out to evaluate the protective and curative effects of Phuong Dong Dai Trang tablets on mustard oil-induced irritable bowel syndrome model in mice. Swiss mice were divided into six groups that were given orally 0.9% sodium chloride (group 1 - 3), Duspatalin (mebeverine) 80 mg/kg b.w./day (group 4), Phuong Dong Dai Trang tablets 1080 mg/kg b.w./day (group 5) and Phuong Dong Dai Trang tablets 3240 mg/kg/b.w./day (group 6). Mice of group 3 - 6 were induced diarrhea-predominant irritable bowel syndrome by mustard oil colonic administration before or after oral treatment. The research indices included the intestinal motility measured by charcoal meal test, colon macroscopic and microscopic scores. Our findings showed that Phuong Dong Dai Trang tablets at 3240 mg/kg b.w./day reduced the intestinal motility and the stool score significantly in mice. Phuong Dong Dai Trang tablets at 1080 mg/kg b.w./day improved the stool score and tended to decrease the intestinal motility in mice.
2 Effects of Phuong Dong Dai Trang tablets on intestinal motility in experimental animals / Tran Thanh Tung, Pham Thi Van Anh, Dau Thuy Duong // .- 2024 .- Volume 184 E15 - N 11 .- P. 1-7 .- 610
Phuong Dong Dai Trang tablets (PDDT) prepared from several medicinal plants, including Hedychium coronarium, Coix lacryma-jobi, Dioscorea persimilis, Cynara Scolymus L., Paeonia lactiflora, Glochidion eriocarpum, are intended to treat gastrointestinal function disorders. This study was carried out to evaluate the effects of PDDT on intestinal motility in vivo and ex vivo. Swiss mice were divided into four groups that were given orally 0.9% sodium chloride, Duspatalin (mebeverine) 80 mg/kg b.w./day, PDDT 1080 mg/kg b.w./day and PDDT 3240 mg/kg/b.w./day, respectively for 5 days. The activated charcoal movements were measured 20 minutes and 40 minutes after all mice were fed with 0.2 ml of 10% activated charcoal. New Zealand White rabbit’s isolated intestinal segments were divided into two groups with two concentrations of PDDT 1350 mg/100 ml Tyrode’s solution and 2025 mg/100 ml Tyrode’s solution, respectively. The intestine’s contractile frequency and amplitude were recorded.
3 Androgenic effects of alcoholic extract from Cnidium monnieri (L.) Cuss fruits in experimental animals / Dau Thuy Duong, Nguyen Tran Thi Giang Huong, Le Minh Ha, Pham Thi Van Anh, Tran Quynh Trang // .- 2024 .- Volume 84 E15 - N 11 .- P. 16-23 .- 615
Traditional medicine used the fruits of Cnidium monnieri (L.) Cuss to treat male hypogonadism and male infertility. This study was carried out to investigate the potential androgenic properties of the alcoholic extract of Cnidium monnieri (L.) Cuss fruits (CFE) in peripubertal castrated male rats. Rats were randomly divided into 5 groups and castrated 7 days before being administered 0.5% CMC, testosterone and CFE at 50 mg/kg/day, 150 mg/kg/day and 250 mg/kg/day, respectively, for 10 days. The relative weight of five target androgen-dependent organs (including seminal vesicles (SV), ventral prostate (VP), paired Cowper’s glands (COW), glans penis (GP) and levator ani-bulbocavernosus (LABC) muscle and blood testosterone level were evaluated.
4 Safety investigation of “Thong Ta Yeu Phuong” capsules: Assessment of acute and subchronic toxicity in the experiment / Le Hong Phu, Nguyen Cong Thuc, Dinh Thu Thu Hang // .- 2024 .- Volume 177 E14 - N 04 - May .- P. 98-105 .- 615
“Thong ta yeu phuong” capsules contained natural materials including Atractylodes macrocephala Koidz., Paeonia lactiflora Pall., Pericarpium Citri Reticulatae, and Ligusticum brachylobum Franch. “Thong ta yeu phuong” capsules were intended to support treating gastrointestinal disorders. So far, the safety of this product, however, has not yet beenreported. Thus, this study aimed to investigate the acute and subchronic toxicities of “Thong ta yeu phuong” capsules through oral administration in experimental animals.
5 Acute and sub-chronic toxicities of phatra tricholes capsule in experimental animals / Tran Thanh Tung, Nguyen Thanh Binh, Dang Thi Thu Hien // .- 2024 .- Volume 177 E14 - N 04 - May .- P. 115-123 .- 615
Phatra Tricholes capsule is a multiplant production planned for dyslipidemia patients. Herein, we assessed the potential toxicity of Phatra Tricholes, applying the protocol of acute and sub-chronic oral administration in experimental animal models. According to the WHO guidelines, the acute toxicity study was conducted on Swiss mice.
6 Experimental animal research on the subchronic toxicity of “Dứa Tre Lão Nhà Quê” extract / Pham Thi Van Anh, Vu Viet Hang, Nguyen Thi Thuy, Dau Thuy Duong // .- 2024 .- Volume 177 E14 - N 04 - May .- P. 124-131 .- 615
“Dứa tre Lão nhà quê” extract (DTLNQ extract) was intended to treat several diseases such as dyslipidemia and venous insufficiency. To provide information on the its safety, this study evaluated the subchronic toxicity of DTLNQ extract. Wistar rats were divided into three groups and were given orally for 12 weeks. General conditions and body weight change, hematological and biochemical parameters, and hepatic and renal histological examinations were evaluated in treated rats compared with the control group and baseline.
7 Nasal irritation of Mui Xoang Nhat Nhat spray in experimental animals / Pham Thi Van Anh, Nguyen Thi Thuy, Nguyen Quoc Hoai, Dau Thuy Duong // .- 2024 .- Volume 177 E14 - N 04 - May .- P. 132-138 .- 615
Mui xoang Nhat Nhat (MXNN) spray is a herbal combination of Angelica dahurica, Xanthium strumarium L., Ageratum conyzoides L, which is intended to use as the supportive treatment of stuffy nose, runny nose in some upper respiratory diseases such as rhinitis and sinusitis. This study was carried out to evaluate the nasal mucosa irritation of MXNN spray in experimental animals.
8 Evaluation of acute and subchronic toxicity of “Huyet Phu Truc U Hoan” in experimental animals / Dang Cong Thai, Trinh Hoai Nam, Nguyen Minh Hien, Dang Thi Thu Hien // .- 2024 .- Volume 177 E14 - N 04 - May .- P. 139-148 .- 615
This research was carried out to evaluate the acute and sub-chronic toxicity of ‘‘Huyet phu truc u hoan’’ (HPTUH) in experimental animals. The acute toxicity was defined on Swiss mice by the Litchfield – Wilcoxon’s method and the sub-chronic toxicity on Wistar rat’s hematopoietic function, liver, and kidney functions according to the World Health Organization Guidance.
9 Evaluation of subchronic toxicity of diabetna capsules in experimental animals / Le Hong Oanh, Hoang Minh Chau, Khuat Van Manh, Phuong Thien Thuong, Dau Thuy Duong, Tran Quynh Trang, Pham Thi Van Anh, Dinh Thi Thu Hang, Nguyen Thi Thuy // .- 2024 .- Volume 177 E14 - N 04 - May .- P. 149-157 .- 615
This research aimed to evaluate the subchronic toxicity of Diabetna capsules through oral administration in experimental animals. The subchronic toxicity was studied in Wistar rats with oral doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16 g/kg/day (3 times as high as recommended human dose) in consecutive 12 weeks, following guidance from the World Health Organization and Organisation for Economic Co-operation and Development.
10 In silico study of cytochrome P450 alleles and phenotypic distribution in Vietnamese population / Pham Ngoc Ha, Nguyen Phan Tuan, Trinh Thi Xuan, Truong Nam Hai, Tran Dang Hung, Nguyen Cuong // Công nghệ sinh học - Vietnam Journal of Biotechnology .- 2022 .- Vol 20 - N2 .- P. 197-212 .- 615
Cytochrome P450 enzymes play an important role in phase I drug metabolism, accounting for approximately 75% of the enzymatic processes. We investigated the allele and phenotypic distributions of five important CYPgenes (CYP2B6, CYP3A5, CYP2C9, CYP2C19, CYP2D6) in the Vietnamese population by using Stargazer and the PharmCAT tool to call star alleles and translating them into phenotypes based on the available dataset of PharmGKB. We compared our computational analysis of the Vietnamese distributions with those of East Asia, Europe, America and other super populations,as well aswith previous experimental research. The allele frequencies and phenotypic distributions of the five important CYPgenes in the Vietnamese population are similar to those in East Asia while significantly different fromother populations. In silico analysis also provided consistent results with previous experimental studies. In addition, the resultant data from our research contributes to the database of genetic variations in pharmacogenetics and constructs the fundamentals for future basic and applied research.