CSDL Bài trích Báo - Tạp chí
chủ đề: Pharmacology
1 In vivo assessment of acute and subchronic toxicity of Nanochitin in experimental animals / Nguyen Thi Cha, Ho Phu Ha, Nguyen Tien Thanh, Bui Tien Hung, Pham Thi Van Anh, Nguyen Thi Thanh Ha, Trinh Vinh Quang, Dinh Thi Thu Hang // .- 2025 .- Tập 190 - Số 5E16 .- P. 137-144 .- 615
This study aimed to evaluate the safety of Nanochitin through oral administration in experimental animals. The acute toxicity was determined in mice at ascending doses and the subchronic toxicity was evaluated in rats with oral doses of 15.6 mg/kg b.w/day and 46.8 mg/kg b.w/day for 30 days.
2 Experimental evaluation of the subchronic toxicity of Phong Te Thap Ba Giang / Pham Thi Van Anh, Bui Tien Hung, Vu Xuan Hai, Nguyen Thi Ha, Dau Thuy Duong // .- 2025 .- Tập 190 - Số 5E16 .- P. 145-152 .- 610
Musculoskeletal disorders have become a global health burden. Phong Te Thap Ba Giang is a traditional medicine that has been used for a long time to treat various musculoskeletal disorders. This study was conducted to evaluate the subchronic toxicity of Phong te thap Ba Giang in experimental animals.
3 An experimental study on the skin irritant potential of Dinh Tho patch / Dam Thi Tu Anh, Pham Thi Van Anh, Do Thi Minh Phuong, Hoang My Hanh, Le Hai Trung, Dau Thuy Duong // .- 2025 .- Tập 190 - Số 5E16 .- P. 153-158 .- 615
Dinh Tho patches are the transdermal combination of medicinal herbs including Dracaena cambodiana Pierre ex Gagnep, Cinnamomum cassia, Kaempferia galanga, Homalomena occulta, Caesalpinia sappan, Illicium verum, Artemisia vulgaris and Reynoutria japonica with the intended indication to treat symptoms of swelling, bruising, tension and pain of the musculoskeletal system. This study was carried out to examine the skin irritation of Dinh Tho patches in experimental animals.
4 A 90-day toxicological assessment of KRG hard capsules containing a water extract of Korean red ginseng in Wistar rats / Yang Deok-Chun, Pham Thi Van Anh, Cho Young Mi, Kwon Jeong Eun, Nguyen Thi Thuy, Kang Se Chan, Kong Byoung Man, Choi Sung Keun, Hoang Van An, Doan Ha Thang, Bui Thi Huong Thao, Dinh Thi Thu Hang, Dang Thi Ngoc Mai, Dang Thi Thu Hien, Mai Phuong Thanh // .- 2025 .- Tập 190 - Số 5E16 .- P. 159-168 .- 615
The KRG hard capsule was produced by Daedong Korea Ginseng Co. Ltd., with Korean red ginseng (Panax ginseng C. A. Meyer) as its primary component. This study aimed to assess the toxicity of KRG following 90 days of repeated oral dosing. Male and female Wistar rats received the test capsule orally once daily at 120 and 360 mg/kg/day over 90 days. The Korean red ginseng extract administration did not lead to any significant toxicological effects regarding mortality, body weight, hematological parameters, serum biochemistry, gross pathological observations, or histopathological analysis. Consequently, based on this toxicological evaluation, the KRG hard capsules are considered safe and non-toxic. The findings may serve as adequate preclinical evidence to support the initiation of future clinical trials involving KRG.
5 Evaluating the acute toxicity and hepatoprotective effect of PROTECFUL hard capsule on paracetamol-induced acute hepatitis in mice / Tran Thanh Tung, La Que Lam, Nguyen Thi Thanh Loan // .- 2025 .- Tập 190 - Số 5E16 .- P. 169-178 .- 615
Drug-induced liver injury is characterized by liver damage due to pharmaceutical compounds, resulting in a wide range of liver disorders, from asymptomatic elevations in liver enzymes to full liver failure. It is a leading cause of acute liver failure in many countries. This study investigated the acute toxicity and evaluated hepatoprotective effects on paracetamol-induced acute hepatitis of PROTECFUL hard capsules in Swiss mice. The acute toxicity was assessed through oral administration, and a fifty percent lethal dose was determined using the Litchfield-Wilcoxon method.
6 In vitro xanthine oxidase inhibitory and in vivo hypouricemic activity of dual herbal combination comprising Carica papaya L. and Piper lolot C. DC leaves / Phan Hong Minh, Ho My Dung, Le Anh Tuan , Nguyen Thuc Thu Huong, Tran Thi Hong Ngoc, Nguyen Thi Thu Hien, Mai Phuong Thanh // .- 2025 .- Tập 190 - Số 5E16 .- P. 179-187 .- 615
Hyperuricemia has emerged as a major public health issue in recent years, with existing treatments often associated with negative side effects for patients. This research examined the anti-hyperuricemic properties of a dual herbal extract made from Carica papaya L. and Piper lolot C.DC leaves, utilizing a xanthine oxidase inhibitory assay and a hyperuricemic mouse model induced by potassium oxonate (500 mg/kg body weight).
7 Anti-inflammatory effects of the extracts from Ardisia silvestris Pitard leaves in experiment / Mai Phuong Thanh, Ho My Dung, Le Anh Tuan, Nguyen Thuc Thu Huong, Tran Thi Hong Ngoc, Le Thi Le Giang, Phan Hong Minh // .- 2025 .- Tập 190 - Số 5E16 .- P. 188-195 .- 615
This research aimed to explore the anti-inflammatory effects of n-hexane, ethyl acetate (EtOAc), and n-butanol extracts from the leaves of Ardisia silvestris Pitard, both in vitro and in vivo, specifically focusing on the EtOAc extract. The in vitro assessment of anti-inflammatory activity involved measuring the inhibition of nitric oxide (NO) production in LPS-stimulated RAW 264.7 macrophage cells. The findings revealed that the EtOAc extract exhibited the highest potency, with an IC50 value of 52.10 ± 2.07 µg/mL, effectively inhibiting NO production without causing cellular damage. In vivo, the EtOAc extract’s anti-inflammatory properties were evaluated using carrageenan-induced paw edema in rats and the cotton pellet-induced granuloma test in mice. At both tested dosages, the EtOAc extract significantly reduced paw edema induced by carrageenan in rats. Additionally, it effectively inhibited exudate and granuloma formation following cotton pellet implantation at both doses, indicating its anti-inflammatory activity during the subacute phase of inflammation. Overall, these results strongly suggest that the ethyl acetate extract of Ardisia silvestris Pitard possesses significant anti-inflammatory properties and may be beneficial in traditionally treating various inflammatory conditions.
8 Effectiveness and safety of LX1 cream in the clinical treatment of facial contusions / Bui Tien Hung, Duong Trung Kien, Bui Anh Tung, Nguyen Tuyet Trang // .- 2025 .- Tập 1907 - Số 5E16 .- Tr. 112-119 .- 615
This research was conducted to evaluate the effectiveness and safety of LX1 cream in the clinical treatment of facial contusions. The study was conducted on 66 patients diagnosed with facial contusions, divided into 2 groups: Control group with patients treated according to the anti-inflammatory, analgesic and anti-edema protocol currently used in the department. Study group with patients treated according to the anti-inflammatory, analgesic and anti-edema protocol currently used in the department combined with the application of LX1 cream.
9 Protective and curative effects of Phuong Dong Dai Trang tablets on an experimental model of irritable bowel syndrome / Tran Thanh Tung, Pham Thi Van Anh, Dau Thuy Duong // .- 2024 .- Volume 184 E15 - N 11 .- P. 87-95 .- 615
Phuong Dong Dai Trang tablet is a mixture of medicinal herbs including Hedychium coronarium, Coix lacryma-jobi, Dioscorea persimilis, Cynara Scolymus L., Paeonia lactiflora, and Glochidion eriocarpum. This study was carried out to evaluate the protective and curative effects of Phuong Dong Dai Trang tablets on mustard oil-induced irritable bowel syndrome model in mice. Swiss mice were divided into six groups that were given orally 0.9% sodium chloride (group 1 - 3), Duspatalin (mebeverine) 80 mg/kg b.w./day (group 4), Phuong Dong Dai Trang tablets 1080 mg/kg b.w./day (group 5) and Phuong Dong Dai Trang tablets 3240 mg/kg/b.w./day (group 6). Mice of group 3 - 6 were induced diarrhea-predominant irritable bowel syndrome by mustard oil colonic administration before or after oral treatment. The research indices included the intestinal motility measured by charcoal meal test, colon macroscopic and microscopic scores. Our findings showed that Phuong Dong Dai Trang tablets at 3240 mg/kg b.w./day reduced the intestinal motility and the stool score significantly in mice. Phuong Dong Dai Trang tablets at 1080 mg/kg b.w./day improved the stool score and tended to decrease the intestinal motility in mice.
10 Effects of Phuong Dong Dai Trang tablets on intestinal motility in experimental animals / Tran Thanh Tung, Pham Thi Van Anh, Dau Thuy Duong // .- 2024 .- Volume 184 E15 - N 11 .- P. 1-7 .- 610
Phuong Dong Dai Trang tablets (PDDT) prepared from several medicinal plants, including Hedychium coronarium, Coix lacryma-jobi, Dioscorea persimilis, Cynara Scolymus L., Paeonia lactiflora, Glochidion eriocarpum, are intended to treat gastrointestinal function disorders. This study was carried out to evaluate the effects of PDDT on intestinal motility in vivo and ex vivo. Swiss mice were divided into four groups that were given orally 0.9% sodium chloride, Duspatalin (mebeverine) 80 mg/kg b.w./day, PDDT 1080 mg/kg b.w./day and PDDT 3240 mg/kg/b.w./day, respectively for 5 days. The activated charcoal movements were measured 20 minutes and 40 minutes after all mice were fed with 0.2 ml of 10% activated charcoal. New Zealand White rabbit’s isolated intestinal segments were divided into two groups with two concentrations of PDDT 1350 mg/100 ml Tyrode’s solution and 2025 mg/100 ml Tyrode’s solution, respectively. The intestine’s contractile frequency and amplitude were recorded.