CSDL Bài trích Báo - Tạp chí
Cytokine inhibitory activity of eurycomanone in RAW 264.7 cells stimulated with viral-mimicking poly (I:C)
Tác giả: Nguyen Thi Ha Trang, Tran Thu Trang, Nguyen Trung Nam
Số trang:
P. 435-441
Số phát hành:
Vol 21 - Number 3
Kiểu tài liệu:
Tạp chí trong nước
Nơi lưu trữ:
03 Quang Trung
Mã phân loại:
610
Ngôn ngữ:
Tiếng Anh
Từ khóa:
Eurycomanone, poly (I:C), RAW 264.7 cells, inflammatory cytokines
Chủ đề:
Virus diseases--Transmission
Tóm tắt:
Poly (I:C) (Polyinosinic:polycytidylic acid) is a synthetic analog of double-stranded RNA binding toll-like receptor 3 (TLR3) and mimicking a virus infection in macrophage. These results suggested that eurycomanone has a potentially regulatory role on production of both pro-inflammatory and anti-inflammatory cytokines in macrophage in the mimicking context of virus infection. Whether eurycomanone inhibits the binding of poly (I:C)-TLR3 or intracellular signaling pathways needs further investigation.