Tóm tắt:

Zika virus (ZIKV) belongs to the flavivirus family, and infection with ZIKV can lead to microcephaly, neurological issues like Guillain-Barré syndrome, and other birth defects. Zika virus can cause serious complications during pregnancy, such as delivery complications and pregnancy problems. It can also lead to severe illnesses, including swelling of the brain and spinal cord, as well as bleeding disorders. The Zika virus gained worldwide attention during the pandemic in Brazil, which led to extensive research efforts to discover effective and safe anti-Zika virus therapies. ADME prediction study found that echinocystic acid, eclalbasaponin I, and ecliptasaponin A have inhibitory abilities and are highly pharmacologically active, while α-amyrin and ursolic acid showed no results. However, all five substances are insoluble and lack optimal saturation, making oral absorption limited.