CSDL Bài trích Báo - Tạp chí
chủ đề: Medicine
1 Title of the article: Cigarette smoking and its association with hiv viral load among HIV-positive opioid users in Vietnam / Nguyen Truong Giang, Nguyen Van Huy, Nguyen Bich Diep, Nguyen Thu Trang, Le Minh Giang // .- 2023 .- Tập 173 - Số 12 - Tháng 12 .- P. 219-228 .- 610
The study aimed to determine the smoking prevalence and explore the association between smoking and viral load among people living with HIV who are drug users (HIV+ PWID) in Vietnam. We used secondary data from a descriptive cross-sectional study of 280 HIV+ PWID in an open-label, non-inferiority trial from July 2015 to February 2018 at six HIV clinics in Northern Vietnam.
2 Characteristics of self-learning techniques of medical students at Hanoi Medical University and related factors / Phan Thi Minh Ngoc, Vu Quoc Trung, Pho Tuan Vinh, Dang Huy Hieu, Nguyen Minh Hien // .- 2023 .- Tập 173 - Số 12 - Tháng 12 .- P. 240-248 .- 610
Research aimed to provide Hanoi Medical University students who experienced a novel study program with insights into ten major self-learning techniques. This descriptive cross-sectional study was conducted among second year to six year general practitioners at Hanoi Medical University, which described the correlation between self-learning techniques and related factors.
3 Analgesic effects of ich phu dan capsules in experimental animals / Pham Thanh Tung, Ninh Thi To Anh, Pham Quoc Su, Nguyen Thi Lan, Pham Viet Hoang, Pham Thi Van Anh, Dau Thuy Duong // .- 2023 .- Tập 173 - Số 12 - Tháng 12 .- P. 267-272 .- 615
Ich phu dan capsules are intended to treat menstrual pain. The study aimed to assess the analgesic effects of Ich phu dan capsules in animal models. Three animal models were used: a hot plate, tail flick and acetic acid-induced writhing test.
4 Acute and sub-chronic toxicological evaluation of Boga -TN tablets in experimental animals / Bui Hoang Anh, Truong Thi Thu Huong, Pham Thanh Tung, Pham Thi Van Anh, Dang Thi Thu Hien, Le Nguyen Thu Dung, Pham Thuy Phuong // .- 2023 .- Tập 173 - Số 12 - Tháng 12 .- P. 18-26 .- 615
Boga-TN is a formula originating from herbal medicines that are used to treat liver disorders; however, its toxicity is not yet investigated. Therefore, this study was conducted to assess the acute and sub-chronic toxicity of Boga-TN tablets in experimental animals. Acute toxicity study was performed via Swiss mice, with a single oral dose, and followed up to seven days according to World Health Organization Guidance. No sign of acute oral toxicity was detected, and the LD50 Boga-TN was estimated to be more than 60.38 g/kg.
5 Evaluation of acute and subchronic toxicities of BTL lozenges on experimental animals / Vu Nam, Pham Ngoc Yen Mi, Pham Thi Van Anh, Duong Trong Nghia, Nguyen Tuong Linh, Tran Thanh Tung // .- 2023 .- Tập 173 - Số 12 - Tháng 12 .- P. 27-36 .- 615
This research evaluated the acute and subchronic toxicities of BTL lozenges through oral administration in experimental animals. The acute toxicity was determined by Litchfield Wilcoxon method in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO and OECD in Wistar rats with oral doses of 720 g/kg body weight/day (equal to recommended human dose) and 1440 g/kg body weight/day (2 times as high as recommended human dose) in 90 consecutive days.
6 Genotoxic evaluation of kovir capsules using mammalian bone marrow chromosomal aberration test / Pham Thi Van Anh, Dau Thuy Duong, Nguyen Huu Thang, Nguyen Thi Huong Lien, Nguyen Thi Hong Van, Mai Phuong Thanh // .- 2023 .- Tập 173 - Số 12 - Tháng 12 .- P. 47-53 .- 615
The genotoxic potential of KOVIR capsules was investigated in vivo using the mammalian bone marrow chromosomal aberration test. Four groups of mice, seven in each group, were used in the study: Group I served as vehicle control; Group II received the positive control (cyclophosphamide 50 mg/kg; single dose; intraperitoneal route); and Group III to IV were given orally the KOVIR capsules, suspended in distilled water, at a single test dose of 2.16 and 4.32 capsules/kg, respectively. The obtained data disclosed the safety of KOVIR capsules, which did not show substantial genotoxic effects at either dose when compared with the vehicle group.
7 Reproductive/developmental toxicity screening test of kovir capsules in mice / Pham Thi Van Anh, Dau Thuy Duong, Nguyen Huu Thang, Nguyen Thi Huong Lien, Nguyen Minh Duc, Mai Phuong Thanh // .- 2023 .- Tập 173 - Số 12 - Tháng 12 .- P. 54-62 .- 615
The present study was performed to gather information on the effects of Kovir capsules on reproductive and developmental parameters in mice according to the OECD guideline for reproductive/developmental toxicity screening test. The test item was administered orally at dose levels of 1.44 and 2.16 capsules/kg body weight/day to male mice from 2 weeks before mating to the end of the 14-day mating period and females from 2 weeks before mating, during mating, gestation, and until the 13th day of lactation. During the study period, clinical signs, body weight, relative organ weight, reproductive and littering results, necropsy results, and histopathological examination of the testicles were examined.
8 Antioxidant and hepatoprotective effects of hypericum sampsonii / Nguyen Viet Dung, Nguyen Duy Thuan, Dang Thi Thu Hien, Pham Thi Van Anh // .- 2023 .- Tập 173 - Số 12 - Tháng 12 .- P. 63-69 .- 615
This study investigates the antioxidant activity and potential hepatoprotective of Hypericum sampsonii extract (BLD1 extract) in vitro and in vivo. The in vitro experiment was carried out with DPPH (1, 1-diphenyl-2-picrylhydrazyl) radical scavenging assay to assess the antioxidant properties of BLD1 extract. In the in vivo experiment, the hepatoprotective activity of BLD1 extract was evaluated on an acetaminophen-induced hepatotoxicity mouse model. The in vitro assay demonstrated that the extract exhibited antioxidant activity in a dose-dependent manner. In the in vivo experiments, BLD1 extract at both doses (3.6 g/kg b.w day and 10.8 g/kg b.w day) reflected the decrease in serum ALT, AST and MDA level. Hepatic histology was also investigated post-mortem to assess the degree of liver injury. The overall findings of this study demonstrate the potential hepatoprotective effect of Hypericum sampsonii in acetaminophen-induced oxidative stress and liver toxicity in mice. This study has established the efficacy of Hypericum sampsonii, which should warrant further clinical trials and applications.
9 Gastroprotective effect of Vien Khoi Tim capsules on indomethacin-induced gastric ulcers in rats / Pham Thi Van Anh, To Le Hong, Nguyen Thi Ha, Nguyen Thi Minh Thu, Pham Thanh Tung, Mai Phuong Thanh // .- 2023 .- Tập 173 - Số 12 - Tháng 12 .- P. 70-78 .- 615
Available anti-ulcer drugs unveil partial effectiveness and numerous adverse reactions. Plants offer an alternative strategy in the search for new drugs in the therapy and prevention of peptic ulceration. The present study investigated the possible protective effect of the herbal formulation Vien Khoi Tim (VKT) on indomethacin-induced gastric mucosal damage in rats. VKT was tested at two doses (1.44 & 0.48 capsules/kg/d po) ten days before the indomethacin single-dose challenge (40 mg/kg po). Animals were sacrificed six hours after indomethacin administration, and gastric tissues were collected for gross observation and histopathological analyses. The results revealed that the administration of indomethacin caused evident gastric mucosal damage with morphological and histological manifestations. VKT pretreatment tended to avert the rise in lesion numbers, reduce the ulcer index, and improve the severity of bleeding streaks and epithelial sloughing in gastric mucosa on the macroscopic examination compared to the model group. It is worth noting that no ulcerative lesions were observed in the gastric tissues of rats receiving VKT upon microscopic examination.
10 Examination of the acute and subchronic oral toxicity of “Com Kien Ty” in experimental animals / Le Hong Phu, Nguyen Cong Thuc, Dinh Thi Thu Hang // .- 2023 .- Tập 173 - Số 12 - Tháng 12 .- P. 79-86 .- 615
Evaluate the acute and subchronic toxicities of “Com kien ty” through oral administration in experimental animals. The acute toxicity was determined using the Litchfield Wilcoxon method in mice. Following WHO's recommendation, the subchronic toxicity was assessed in rabbits with oral doses of 0.9 g/kg/day (equal to the recommended human dose) and 2.7 g/kg/day (3 times as high as the recommended human dose) in 4 consecutive weeks. Results showed “Com kien ty” at the highest dose of 60.0 g/kg did not express acute toxicity in mice. Regarding the subchronic toxicity test, after oral administration of “Com kien ty”, hematological parameters, hepato-renal functions were unchanged as compared with the control group, and no gross lesions in organs were observed in all experimental animals. In conclusion, “Com kien ty” did not produce acute and subchronic toxicities in Swiss mice and New Zealand rabbits.