CSDL Bài trích Báo - Tạp chí
Khoa Dược
1 Effects of FU Plus tablets on intracavernosal pressure in animal experimentsanimals / Pham Thi Van Anh, Do Dieu Linh, Dau Thuy Duong // .- 2025 .- Tập 190 - Số 5E16 .- P. 130-136 .- 615
Erectile dysfunction is defined as the persistent inability to attain and maintain an erection sufficient to permit satisfactory sexual performance, that may affect physical and psychosocial health, and the patients quality of life. A popular trend is to discover and research therapeutic drugs derived from medicinal herbs. FU Plus tablets including Epimedium extract, Tribulus Terrestris Extract, L-Arginine HCl, Red Ginseng extract, Zinc gluconate, Selenium yeast and Yohimbine HCl is a product expected to treat erectile dysfunction. The study was carried out to evaluate the effects of FU Plus tablets on the erectile function through intracavernosal pressure (ICP) in experimental animals. Wistar rats were divided into 3 groups of ten that were given normal saline, sildenafil and FU Plus tablets, respectively. ICP response after cavernous nerve stimulation was recorded. Sildenafil-treated rats and FU Plus-treated rats had shorter response latency, higher peak ICP and longer response duration than untreated control rats. In conclusion, FU Plus tablets have the potential for treating erectile dysfunction.
2 In vivo assessment of acute and subchronic toxicity of Nanochitin in experimental animals / Nguyen Thi Cha, Ho Phu Ha, Nguyen Tien Thanh, Bui Tien Hung, Pham Thi Van Anh, Nguyen Thi Thanh Ha, Trinh Vinh Quang, Dinh Thi Thu Hang // .- 2025 .- Tập 190 - Số 5E16 .- P. 137-144 .- 615
This study aimed to evaluate the safety of Nanochitin through oral administration in experimental animals. The acute toxicity was determined in mice at ascending doses and the subchronic toxicity was evaluated in rats with oral doses of 15.6 mg/kg b.w/day and 46.8 mg/kg b.w/day for 30 days.
3 Experimental evaluation of the subchronic toxicity of Phong Te Thap Ba Giang / Pham Thi Van Anh, Bui Tien Hung, Vu Xuan Hai, Nguyen Thi Ha, Dau Thuy Duong // .- 2025 .- Tập 190 - Số 5E16 .- P. 145-152 .- 610
Musculoskeletal disorders have become a global health burden. Phong Te Thap Ba Giang is a traditional medicine that has been used for a long time to treat various musculoskeletal disorders. This study was conducted to evaluate the subchronic toxicity of Phong te thap Ba Giang in experimental animals.
4 An experimental study on the skin irritant potential of Dinh Tho patch / Dam Thi Tu Anh, Pham Thi Van Anh, Do Thi Minh Phuong, Hoang My Hanh, Le Hai Trung, Dau Thuy Duong // .- 2025 .- Tập 190 - Số 5E16 .- P. 153-158 .- 615
Dinh Tho patches are the transdermal combination of medicinal herbs including Dracaena cambodiana Pierre ex Gagnep, Cinnamomum cassia, Kaempferia galanga, Homalomena occulta, Caesalpinia sappan, Illicium verum, Artemisia vulgaris and Reynoutria japonica with the intended indication to treat symptoms of swelling, bruising, tension and pain of the musculoskeletal system. This study was carried out to examine the skin irritation of Dinh Tho patches in experimental animals.
5 A 90-day toxicological assessment of KRG hard capsules containing a water extract of Korean red ginseng in Wistar rats / Yang Deok-Chun, Pham Thi Van Anh, Cho Young Mi, Kwon Jeong Eun, Nguyen Thi Thuy, Kang Se Chan, Kong Byoung Man, Choi Sung Keun, Hoang Van An, Doan Ha Thang, Bui Thi Huong Thao, Dinh Thi Thu Hang, Dang Thi Ngoc Mai, Dang Thi Thu Hien, Mai Phuong Thanh // .- 2025 .- Tập 190 - Số 5E16 .- P. 159-168 .- 615
The KRG hard capsule was produced by Daedong Korea Ginseng Co. Ltd., with Korean red ginseng (Panax ginseng C. A. Meyer) as its primary component. This study aimed to assess the toxicity of KRG following 90 days of repeated oral dosing. Male and female Wistar rats received the test capsule orally once daily at 120 and 360 mg/kg/day over 90 days. The Korean red ginseng extract administration did not lead to any significant toxicological effects regarding mortality, body weight, hematological parameters, serum biochemistry, gross pathological observations, or histopathological analysis. Consequently, based on this toxicological evaluation, the KRG hard capsules are considered safe and non-toxic. The findings may serve as adequate preclinical evidence to support the initiation of future clinical trials involving KRG.
6 Evaluating the acute toxicity and hepatoprotective effect of PROTECFUL hard capsule on paracetamol-induced acute hepatitis in mice / Tran Thanh Tung, La Que Lam, Nguyen Thi Thanh Loan // .- 2025 .- Tập 190 - Số 5E16 .- P. 169-178 .- 615
Drug-induced liver injury is characterized by liver damage due to pharmaceutical compounds, resulting in a wide range of liver disorders, from asymptomatic elevations in liver enzymes to full liver failure. It is a leading cause of acute liver failure in many countries. This study investigated the acute toxicity and evaluated hepatoprotective effects on paracetamol-induced acute hepatitis of PROTECFUL hard capsules in Swiss mice. The acute toxicity was assessed through oral administration, and a fifty percent lethal dose was determined using the Litchfield-Wilcoxon method.
7 In vitro xanthine oxidase inhibitory and in vivo hypouricemic activity of dual herbal combination comprising Carica papaya L. and Piper lolot C. DC leaves / Phan Hong Minh, Ho My Dung, Le Anh Tuan , Nguyen Thuc Thu Huong, Tran Thi Hong Ngoc, Nguyen Thi Thu Hien, Mai Phuong Thanh // .- 2025 .- Tập 190 - Số 5E16 .- P. 179-187 .- 615
Hyperuricemia has emerged as a major public health issue in recent years, with existing treatments often associated with negative side effects for patients. This research examined the anti-hyperuricemic properties of a dual herbal extract made from Carica papaya L. and Piper lolot C.DC leaves, utilizing a xanthine oxidase inhibitory assay and a hyperuricemic mouse model induced by potassium oxonate (500 mg/kg body weight).
8 Anti-inflammatory effects of the extracts from Ardisia silvestris Pitard leaves in experiment / Mai Phuong Thanh, Ho My Dung, Le Anh Tuan, Nguyen Thuc Thu Huong, Tran Thi Hong Ngoc, Le Thi Le Giang, Phan Hong Minh // .- 2025 .- Tập 190 - Số 5E16 .- P. 188-195 .- 615
This research aimed to explore the anti-inflammatory effects of n-hexane, ethyl acetate (EtOAc), and n-butanol extracts from the leaves of Ardisia silvestris Pitard, both in vitro and in vivo, specifically focusing on the EtOAc extract. The in vitro assessment of anti-inflammatory activity involved measuring the inhibition of nitric oxide (NO) production in LPS-stimulated RAW 264.7 macrophage cells. The findings revealed that the EtOAc extract exhibited the highest potency, with an IC50 value of 52.10 ± 2.07 µg/mL, effectively inhibiting NO production without causing cellular damage. In vivo, the EtOAc extract’s anti-inflammatory properties were evaluated using carrageenan-induced paw edema in rats and the cotton pellet-induced granuloma test in mice. At both tested dosages, the EtOAc extract significantly reduced paw edema induced by carrageenan in rats. Additionally, it effectively inhibited exudate and granuloma formation following cotton pellet implantation at both doses, indicating its anti-inflammatory activity during the subacute phase of inflammation. Overall, these results strongly suggest that the ethyl acetate extract of Ardisia silvestris Pitard possesses significant anti-inflammatory properties and may be beneficial in traditionally treating various inflammatory conditions.
9 Effectiveness and safety of LX1 cream in the clinical treatment of facial contusions / Bui Tien Hung, Duong Trung Kien, Bui Anh Tung, Nguyen Tuyet Trang // .- 2025 .- Tập 1907 - Số 5E16 .- Tr. 112-119 .- 615
This research was conducted to evaluate the effectiveness and safety of LX1 cream in the clinical treatment of facial contusions. The study was conducted on 66 patients diagnosed with facial contusions, divided into 2 groups: Control group with patients treated according to the anti-inflammatory, analgesic and anti-edema protocol currently used in the department. Study group with patients treated according to the anti-inflammatory, analgesic and anti-edema protocol currently used in the department combined with the application of LX1 cream.
10 Mô phỏng dược động học/dược lực học của pyrazinamid trên bệnh nhân lao phổi / Phan Tuấn Đức, Bùi Sơn Nhật, Lê Thị Luyến // Khoa học và công nghệ Việt Nam .- 2025 .- Số 2B .- Tr. 68 - 73 .- 610
Giới thiệu: Pyrazinamid (PZA) có vai trò lớn trong phác đồ chống lao, cần được tối ưu hóa cách sử dụng. Nghiên cứu được tiến hành nhằm xác định khả năng đạt được các đích dược động học/dược lực học (PK/PD) của PZA trong điều trị lao phổi. Phương pháp: 516 mẫu máu của 129 bệnh nhân lao phổi không đa kháng thuốc được thu thập nhằm ghi nhận dữ liệu nồng độ - thời gian của PZA, từ đó xây dựng mô hình dược động học quần thể và mô phỏng Monte Carlo để xác định tỷ lệ đạt các đích PK/PD tại các chế độ liều dựa trên thể trọng và cân nặng trừ mỡ (FFM). Kết quả: Tỷ lệ đạt các đích PK/PD tăng dần khi tăng liều. Với MIC≥50 μg/ml, cần liều 40 mg/kg để trên 80% bệnh nhân đạt đích diện tích dưới đường cong/nồng độ ức chế tối thiểu (AUC/MIC); với liều 30 mg/kg hoặc 35 mg/kg, FFM >90% bệnh nhân đạt đích AUC0-24 và Cmax. Liều dựa trên FFM cho thấy hiệu quả tương tự so với các chế độ dựa trên thể trọng hiện nay. Kết luận: Các chế độ liều tính theo FFM cải thiện tỷ lệ các đích PK/PD của PZA.